His additional feature credits include the horror film House of Wax, with Chad Michael Murray and Paris Hilton; Cry Wolf, as a precocious boarding school student drawn into an elaborate "liar's club" hoax involving a serial killer; Flight of the Phoenix, opposite Dennis Quaid and Hugh Laurie; New York Minute, with Mary-Kate and Ashley Olsen; and Cheaper by the Dozen, starring Steve Martin.
Previously, Padalecki spent two months in Australia filming the lead in the television movie A Ring of Endless Light based on the novel by Madeline L'Engle, and landed the coveted title role in The WB's telefilm Young MacGyver.
In the world of television, he hosted MTV's Room 401. The series, from executive producers Ashton Kutcher and Jason Goldberg, took viewers on a weekly, mind-blowing journey in which talented, up-and-coming illusionists scared and deceived innocent bystanders. Prior to SUPERNATURAL, he had been best known for his starring role as Dean Forester, the boyfriend of Alexis Bledel's character, Rory, on Gilmore Girls.
Padelecki currently resides in Los Angeles with his wife.